drug_type
RELEVANT_DRUG
intervention_type
Biologic (monoclonal antibody)
drug_description
Anti-EGFR monoclonal antibody that blocks EGFR signaling, suppressing the RAS/RAF/MEK/ERK pathway in RAS/BRAF–wild type tumors.
nci_thesaurus_concept_id
C163981
nci_thesaurus_definition
A glycoengineered humanized version of the monoclonal antibody of cetuximab, with potential antineoplastic activity. Upon intravenous administration, pimurutamab selectively targets and binds to the extracellular domain of the epidermal growth factor receptor (EGFR), thereby preventing the activation and subsequent dimerization of the receptor. This may prevent EGFR-mediated signaling and inhibit EGFR-dependent tumor cell proliferation. In addition, the glyco-optimization promotes antibody-dependent cell-mediated cytotoxicity (ADCC). EGFR, a member of the epidermal growth factor family of extracellular protein ligands, may be overexpressed on the cell surfaces of certain tumor types.
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
HLX07 (pimurutamab) is a glycoengineered humanized anti-EGFR monoclonal antibody that binds the extracellular domain of EGFR, blocking ligand binding and receptor dimerization to inhibit EGFR-driven RAS/RAF/MEK/ERK signaling and tumor cell proliferation; glyco-optimization enhances ADCC.
drug_name
HLX07
nct_id_drug_ref
NCT06542588