drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
Adoptive cellular immunotherapy using autologous T lymphocytes genetically engineered to express chimeric antigen receptors that recognize tumor antigens and mediate cytotoxic activity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T lymphocytes are genetically engineered to express a chimeric antigen receptor that binds specific tumor-associated antigens (MHC-independent), activating the T cells to proliferate, release cytotoxic molecules and cytokines, and selectively kill antigen-expressing cancer cells.
drug_name
Chimeric Antigen Receptor (CAR) T-Cell Therapy
nct_id_drug_ref
NCT06414278