drug_type
RELEVANT_DRUG
intervention_type
Biologic (bispecific T-cell–engaging antibody)
drug_description
Alnuctamab (BMS-986349; CC-93269) is a BCMA×CD3 bispecific T-cell–engaging antibody that links CD3 on T cells to BCMA on myeloma cells to trigger T-cell cytotoxicity.
nci_thesaurus_concept_id
C175740
nci_thesaurus_preferred_term
Alnuctamab
nci_thesaurus_definition
A bispecific T-cell engager (BiTE) antibody directed against both the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; TNFRSF17) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, alnuctamab binds bivalently to BCMA expressed on tumor cells and monovalently to CD3 expressed on cytotoxic T-lymphocytes (CTLs). This activates and redirects CTLs to BCMA-expressing tumor cells, which results in the CTL-mediated death of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival.
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Intravenous
drug_mechanism_of_action
Bispecific T‑cell–engaging antibody that binds BCMA on myeloma cells and CD3 on T cells, bringing them into proximity to activate and redirect cytotoxic T cells to kill BCMA‑expressing tumor cells (e.g., via immune synapse formation and perforin/granzyme release).
drug_name
Alnuctamab
nct_id_drug_ref
NCT06121843