drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
Bispecific antibody targeting DLL3 on neuroendocrine tumor cells and CD47 to block the CD47–SIRPα 'don't‑eat‑me' signal, enhancing macrophage phagocytosis and Fc effector functions.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Bispecific
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Bispecific antibody that binds DLL3 on neuroendocrine tumor cells while blocking CD47 to inhibit the CD47–SIRPα 'don't-eat-me' signal, thereby enhancing macrophage-mediated phagocytosis and Fc effector functions (e.g., ADCP/ADCC) against DLL3-positive tumor cells.
drug_name
Peluntamig (PT217)
nct_id_drug_ref
NCT05652686