drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
An individualized mRNA vaccine encoding selected tumor neoantigens; taken up by antigen-presenting cells, translated to neoantigen peptides, and presented on MHC I/II to prime/expand tumor-specific CD8+ and CD4+ T cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Cancer Vaccines
drug_category
mRNA VACCINE
drug_class
Vaccine
drug_delivery_route
Local injection
drug_mechanism_of_action
Individualized mRNA encoding patient-specific tumor neoantigens is taken up by antigen-presenting cells, translated into neoantigen peptides, and presented on MHC I and II, priming and expanding neoantigen-specific CD8+ cytotoxic and CD4+ helper T cells to recognize and kill neoantigen-bearing tumor cells.
drug_name
Patient-specific neoantigen mRNA vaccine
nct_id_drug_ref
NCT06195384