drug_type
RELEVANT_DRUG
intervention_type
cellular therapy (dendritic cell vaccine)
drug_description
Cellular cancer vaccine in which autologous dendritic cells are loaded with WT1 mRNA ex vivo to present WT1 peptides and prime WT1-specific CD8+ and CD4+ T-cell responses.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Dendritic Cell Vaccine
drug_category
DC VACCINE
drug_class
Vaccine
drug_delivery_route
Not specified
drug_mechanism_of_action
Autologous dendritic cells are generated ex vivo and loaded with WT1 mRNA, leading to endogenous processing and presentation of WT1 peptides on MHC I and II to prime and expand WT1-specific CD8+ cytotoxic and CD4+ helper T cells, inducing tumor-specific immunity against WT1-expressing cells.
drug_name
Autologous WT1 mRNA–loaded dendritic cell vaccine
nct_id_drug_ref
NCT05765084