drug_type
RELEVANT_DRUG
intervention_type
Antibody–drug conjugate (ADC)
drug_description
HER2-targeted antibody–drug conjugate carrying MMAE; binds HER2 on tumor cells, is internalized, and releases MMAE to disrupt microtubules, leading to cell-cycle arrest and apoptosis (with potential bystander effect).
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
RC48 antibody
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
HER2-targeted antibody–drug conjugate: disitamab antibody binds HER2 on tumor cells, is internalized, and a cleavable linker releases the cytotoxic payload MMAE, which disrupts microtubules, causing G2/M cell-cycle arrest and apoptosis; the released payload can diffuse to nearby cells (bystander effect).
drug_name
RC48 (disitamab vedotin)
nct_id_drug_ref
NCT06063018