drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
A HER2-targeted antibody–drug conjugate in which a monoclonal antibody binds HER2 (ERBB2) on tumor cells, is internalized, and releases the cytotoxic payload monomethyl auristatin E (MMAE) to disrupt microtubules and induce apoptosis; may exert a bystander effect.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibody-Drug Conjugates
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
HER2-targeted antibody–drug conjugate: an anti-HER2 monoclonal antibody binds ERBB2 on tumor cells, is internalized, and a cleavable linker releases the cytotoxic payload MMAE, a microtubule inhibitor, causing mitotic arrest and apoptosis; the membrane-permeable payload may produce a bystander effect.
drug_name
RC48-ADC (disitamab vedotin)
nct_id_drug_ref
NCT06178601