drug_type
RELEVANT_DRUG
intervention_type
mRNA therapeutic (biologic drug), injection
drug_description
An mRNA therapeutic (injection) that encodes a bispecific T‑cell engager targeting CD19 and CD3. After in vivo translation, the expressed CD19×CD3 engager redirects and activates T cells to kill CD19+ B cells, depleting autoreactive B-cell compartments and reducing autoantibody-producing cells (BiTE-like mechanism).
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
RNA, Messenger
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Intravenous
drug_mechanism_of_action
Injected mRNA is translated in vivo into a bispecific CD19xCD3 T‑cell engager that links CD3 on T cells to CD19 on B cells, redirecting and activating T cells to kill CD19+ B cells and deplete autoreactive, autoantibody‑producing compartments.
drug_name
ABO2203
nct_id_drug_ref
NCT06747156