drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
A human afucosylated IgG1 monoclonal antibody (AMG 451; KHK4083) administered subcutaneously that targets OX40 (CD134), blocks OX40–OX40L signaling to reduce T-cell activation and survival, and mediates ADCC to deplete OX40-positive activated T cells.
nci_thesaurus_concept_id
C184936
drug_mesh_term
Antibodies, Monoclonal
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Subcutaneous
drug_mechanism_of_action
Human afucosylated IgG1 monoclonal antibody targeting OX40 (CD134) that blocks OX40–OX40L co-stimulatory signaling to reduce T-cell activation and survival, with enhanced ADCC to deplete OX40-positive activated T cells.
drug_name
Rocatinlimab
nct_id_drug_ref
NCT06214481