drug_type
RELEVANT_DRUG
intervention_type
Antibody–Drug Conjugate (ADC)
drug_description
A HER2-targeted antibody–drug conjugate with a cleavable linker to a topoisomerase I inhibitor payload; binds HER2, internalizes, and releases the payload to induce DNA damage while retaining HER2 blockade and ADCC.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
HER2-targeted monoclonal antibody conjugated via a cleavable linker to a topoisomerase I inhibitor; binds HER2 on tumor cells, internalizes, and releases the cytotoxic payload to inhibit Topo I and induce DNA damage–mediated cell death, while also blocking HER2 signaling and engaging ADCC.
drug_name
DB-1303 (BNT323)
nct_id_drug_ref
NCT06265428