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drug_type
RELEVANT_DRUG
intervention_type
Biological (bispecific monoclonal antibody)
drug_description
An anti-CD20 × anti-CD3 T-cell–redirecting bispecific monoclonal antibody that engages CD3+ T cells and CD20+ B cells to induce cytotoxicity in malignant B cells.
nci_thesaurus_concept_id
C119615
nci_thesaurus_preferred_term
Odronextamab
nci_thesaurus_definition
A bispecific, human monoclonal antibody with potential antineoplastic activity. Anti-CD20/CD3 monoclonal antibody REGN1979 contains two antigen-recognition sites: one for human CD3, a T cell surface antigen, and one for human CD20, a tumor-associated antigen that is exclusively expressed on B-cells during most stages of B-cell development and is often overexpressed in B-cell malignancies. Upon administration, odronextamab binds to both T-cells and CD20-expressing tumor B-cells, which cross-links the T-cells to tumor cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against CD20-expressing tumor B-cells.
drug_mesh_term
Antibodies, Bispecific
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Intravenous
drug_mechanism_of_action
Bispecific anti-CD20×anti-CD3 antibody that simultaneously binds CD20 on B cells and CD3 on T cells, crosslinking them to form an immune synapse and activate T cells to kill CD20+ malignant B cells via redirected cytotoxicity (perforin/granzyme and cytokine-mediated effects).
drug_name
Odronextamab
nct_id_drug_ref
NCT05685173