drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR T cells)
drug_description
Autologous, lentivirally transduced chimeric antigen receptor (CAR) T-cell therapy engineered to express a CAR targeting glycoprotein non-metastatic B (GPNMB) on tumor cells, leading to CAR-mediated T-cell activation and cytotoxic killing of GPNMB-expressing cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells are lentivirally transduced to express a chimeric antigen receptor targeting GPNMB on tumor cells; CAR engagement activates the T cells and induces cytotoxic killing of GPNMB-expressing cells.
drug_name
GCAR1
nct_id_drug_ref
NCT06827886