drug_type
RELEVANT_DRUG
intervention_type
Cellular vaccine (autologous dendritic cell)
drug_description
Autologous dendritic cell (cellular) vaccine loaded with the circular RNA–encoded cryptic peptide CircFAM53B-219aa; HLA-A*02:01–restricted; primes antigen-specific CD8+ T cells via MHC-I presentation against tumors with high CircFAM53B expression.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Vaccines, Dendritic Cell
drug_category
DC VACCINE
drug_class
Vaccine
drug_delivery_route
Not Reported
drug_mechanism_of_action
Autologous dendritic cells loaded with the circular RNA–encoded cryptic peptide CircFAM53B-219aa (HLA-A*02:01–restricted) present the antigen via MHC class I to prime antigen-specific CD8+ T cells, promoting cytotoxic T-cell responses against tumors with high CircFAM53B expression.
drug_name
CircFam53B-219aa DC vaccine
nct_id_drug_ref
NCT06530082