drug_type
RELEVANT_DRUG
intervention_type
Drug (antibody–drug conjugate)
drug_description
Therapeutic monoclonal antibody–drug conjugates that bind cell-surface Trop2, internalize, and release a cytotoxic payload to kill Trop2-positive tumor cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibody-Drug Conjugates
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Monoclonal antibody binds cell-surface Trop2 on tumor cells, undergoes receptor-mediated internalization, and linker cleavage releases an intracellular cytotoxic payload (e.g., topoisomerase I inhibitor), causing DNA damage and tumor cell death with potential bystander effect in Trop2-positive cancers.
drug_name
Trop2-targeted antibody–drug conjugates
nct_id_drug_ref
NCT07046689