drug_type
RELEVANT_DRUG
intervention_type
Biological (monoclonal antibody)
drug_description
CD44v6-targeting monoclonal antibody used as the targeting moiety for radioimmunotherapy; binds the CD44v6 isoform on tumor cells to deliver the attached radionuclide.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Monoclonal
drug_category
RADIOIMMUNOCONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
A CD44v6-targeting monoclonal antibody labeled with lutetium-177 that binds CD44v6 on tumor cells and delivers localized beta radiation, inducing DNA damage (including double-strand breaks) and tumor cell death, with a cross-fire effect to nearby CD44v6-positive cells.
drug_name
AKIR001
nct_id_drug_ref
NCT06639191