drug_type
RELEVANT_DRUG
intervention_type
Radiopharmaceutical
drug_description
Beta-emitting therapeutic radionuclide conjugated to AKIR001 to deliver localized ionizing radiation, causing DNA damage and tumor cell death with potential cross-fire effects.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Lutetium
drug_category
RADIOIMMUNOCONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Lutetium-177 is a beta-emitting radionuclide linked to the CD44v6-targeting monoclonal antibody AKIR001. Upon binding CD44v6 on tumor cells, it delivers localized ionizing radiation that induces DNA double-strand breaks and tumor cell death, with cross-fire effects on neighboring tumor cells.
drug_name
Lutetium-177
nct_id_drug_ref
NCT06639191