drug_type
RELEVANT_DRUG
intervention_type
Monoclonal antibody (immunotherapy), intravenous
drug_description
Intravenous anti-CD38 monoclonal antibody, 16 mg/kg weekly for 8 doses; binds CD38 on plasma cells (including long-lived autoreactive plasma cells/plasmablasts), depleting them via Fc-mediated effector functions (ADCC/CDC/ADCP) and apoptosis to reduce pathogenic anti-platelet autoantibodies in pediatric refractory/relapsed ITP.
nci_thesaurus_concept_id
C155321
nci_thesaurus_preferred_term
Anti-CD38 Monoclonal Antibody
nci_thesaurus_definition
Any monoclonal antibody that is directed against the CD38 antigen.
drug_mesh_term
Antibodies, Monoclonal, Humanized
drug_category
CYTOTOXIC ANTIBODY
drug_class
Cytotoxic protein
drug_delivery_route
Intravenous
drug_mechanism_of_action
Humanized anti‑CD38 monoclonal antibody that binds CD38 on plasma cells/plasmablasts and depletes them via Fc‑mediated effector functions (ADCC, CDC, ADCP) and apoptosis, reducing pathogenic anti‑platelet autoantibodies in ITP.
drug_name
Anti-CD38 monoclonal antibody
nct_id_drug_ref
NCT06168851