drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (autologous dendritic cell vaccine)
drug_description
Autologous dendritic cell cancer vaccine engineered to present WT1 antigens via MHC I/II and surface-display the IL-15/IL-15Rα complex to enhance CD8+ T-cell and NK-cell activation, proliferation, cytotoxicity, and memory.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Dendritic Cell Vaccine
drug_category
DC VACCINE
drug_class
Vaccine
drug_delivery_route
Not specified
drug_mechanism_of_action
Autologous dendritic cells engineered to present WT1 antigens on MHC I/II and to surface-transpresent the IL-15/IL-15Ralpha complex, thereby priming and expanding WT1-specific CD8+ and CD4+ T cells and enhancing CD8+ T-cell and NK-cell activation, proliferation, cytotoxicity, survival, and memory via IL-15 signaling.
drug_name
IL15-transpresenting WT1-targeted Dendritic Cell Vaccine
nct_id_drug_ref
NCT05964361