drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
An anti-HER2 antibody–drug conjugate that binds HER2 (ERBB2) on tumor cells, internalizes, and releases the cytotoxic payload MMAE to inhibit microtubules, causing G2/M arrest and apoptosis, with potential bystander killing.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Disitamab Vedotin
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Anti-HER2 (ERBB2) antibody–drug conjugate that binds HER2 on tumor cells, is internalized, and releases the microtubule inhibitor MMAE to disrupt tubulin polymerization, causing G2/M arrest and apoptosis, with potential bystander killing.
drug_name
Disitamab vedotin (RC48)
nct_id_drug_ref
NCT05720533