drug_type
RELEVANT_DRUG
intervention_type
Antibody–drug conjugate (ADC)
drug_description
CDH6-directed antibody–drug conjugate; a monoclonal antibody targeting Cadherin-6 that is internalized and releases a deruxtecan (DXd; exatecan-derivative) topoisomerase I inhibitor payload to cause DNA damage and apoptosis.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibody-Drug Conjugates
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
CDH6-targeted antibody–drug conjugate; the anti-CDH6 mAb binds Cadherin-6 on tumor cells, is internalized, and releases a deruxtecan (DXd; exatecan-derivative) topoisomerase I inhibitor payload that induces DNA damage (single-strand breaks), leading to cell cycle arrest and apoptosis, with potential bystander killing.
drug_name
Raludotatug deruxtecan (R-DXd; DS-6000a)
nct_id_drug_ref
NCT06161025