drug_type
RELEVANT_DRUG
intervention_type
monoclonal antibody (biologic)
drug_description
Human anti-CD2 monoclonal antibody biologic that binds CD2 on T cells and NK cells, blocks LFA-3/CD2 costimulation, and preferentially depletes/modulates CD2hi effector-memory T cells while relatively sparing regulatory T cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Siplizumab
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Human anti-CD2 monoclonal antibody that binds CD2 on T cells and NK cells, blocks LFA-3/CD2 costimulation, and preferentially depletes/modulates CD2hi effector-memory T cells while relatively sparing regulatory T cells, suppressing alloreactive responses.
drug_name
Siplizumab (TCD601)
nct_id_drug_ref
NCT04803006