drug_type
RELEVANT_DRUG
intervention_type
antibody–drug conjugate (TROP2-targeted)
drug_description
A TROP2-targeted antibody–drug conjugate that binds TROP2 on tumor cells, is internalized, and releases a camptothecin-derived topoisomerase I inhibitor payload to induce DNA damage and cell death (with potential bystander effect).
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibody-Drug Conjugates
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
TROP2-targeted antibody–drug conjugate that binds TROP2 on tumor cells, is internalized, and releases a camptothecin-derived topoisomerase I inhibitor payload to cause DNA damage and tumor cell death, with potential bystander effect.
drug_name
Sacituzumab tirumotecan (MK-2870, SKB264)
nct_id_drug_ref
NCT06305754