drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
A biologic antibody targeting CD20 that depletes CD20-positive B cells to reduce humoral sensitization prior to kidney transplantation.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Monoclonal
drug_category
CYTOTOXIC ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Monoclonal antibody that binds CD20 on B cells and depletes CD20+ B-cell populations via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, thereby reducing humoral responses (e.g., anti-HLA antibody production) prior to transplantation.
drug_name
anti-CD20 monoclonal antibody
nct_id_drug_ref
NCT05785936