drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR T cells)
drug_description
Autologous gamma delta T cells engineered with a chimeric antigen receptor targeting Prostate Stem Cell Antigen (PSCA), redirecting γδ T-cell activation and cytotoxicity against PSCA-positive tumor cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous gamma delta T cells engineered with a PSCA-specific chimeric antigen receptor bind PSCA on tumor cells, triggering MHC-independent activation, cytokine release, and perforin/granzyme-mediated cytotoxicity against PSCA-positive cancer cells.
drug_name
MSGV1-PSCA-8T28Z
nct_id_drug_ref
NCT06193486