drug_type
RELEVANT_DRUG
intervention_type
Antibody-drug conjugate (B7-H3–targeted, topoisomerase I inhibitor payload)
drug_description
A B7-H3–targeted antibody-drug conjugate that binds B7-H3 on tumor cells, is internalized, and releases a deruxtecan topoisomerase I inhibitor payload to induce DNA damage and tumor cell death (with potential bystander effect).
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Monoclonal antibody targets B7-H3 on tumor cells, undergoes internalization, and releases a deruxtecan topoisomerase I inhibitor payload that induces DNA damage and tumor cell death, with potential bystander killing.
drug_name
Ifinatamab deruxtecan (I-DXd)
nct_id_drug_ref
NCT06362252