drug_type
RELEVANT_DRUG
intervention_type
Biologic (monoclonal antibody)
drug_description
Humanized IgG1 monoclonal antibody targeting EGFR; blocks ligand binding and downstream signaling (RAS/RAF/MEK/ERK, PI3K/AKT), mediates ADCC, and enhances radiosensitivity in EGFR-overexpressing HNSCC.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Nimotuzumab
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Humanized IgG1 monoclonal antibody against EGFR that blocks ligand binding and receptor activation, suppressing downstream RAS/RAF/MEK/ERK and PI3K/AKT signaling; its Fc can engage immune effector cells to mediate ADCC, and EGFR blockade can enhance tumor radiosensitivity, particularly in EGFR-overexpressing HNSCC.
drug_name
Nituozumab
nct_id_drug_ref
NCT05831930