drug_type
RELEVANT_DRUG
intervention_type
Biologic (polyclonal antibody)
drug_description
Polyclonal anti–T-cell antibody that depletes recipient lymphocytes to facilitate donor cell engraftment.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antithymocyte Globulin
drug_category
CYTOTOXIC ANTIBODY
drug_class
Cytotoxic protein
drug_delivery_route
Intravenous
drug_mechanism_of_action
Polyclonal anti-thymocyte IgG that binds multiple T-cell surface antigens and depletes lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, leading to profound T-cell immunosuppression to facilitate donor cell engraftment.
drug_name
Rabbit anti-thymocyte globulin (rATG)
nct_id_drug_ref
NCT05806749