drug_type
RELEVANT_DRUG
intervention_type
Biologic - monoclonal antibody
drug_description
A human IgG1 monoclonal antibody targeting OX40 (CD134) on activated T cells; blocks OX40–OX40L costimulation and can deplete OX40+ T cells to reduce type‑2 inflammation.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Subcutaneous
drug_mechanism_of_action
Human IgG1 monoclonal antibody that binds OX40 (CD134) on activated T cells, blocking OX40–OX40L costimulatory signaling and, via Fc effector functions, can deplete OX40+ T cells, reducing type‑2 (Th2) inflammation.
drug_name
Rocatinlimab (AMG 451)
nct_id_drug_ref
NCT05891119