drug_type
RELEVANT_DRUG
intervention_type
Cellular vaccine (autologous dendritic-cell immunotherapy)
drug_description
An autologous, type-1–polarized dendritic-cell vaccine pulsed with peptides from native and mutated ESR1; administered intranodally or intratumorally to present antigen via MHC I/II and prime Th1/CD8+ T-cell responses against ER/ESR1-mutant tumor cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Cancer Vaccines
drug_category
DC VACCINE
drug_class
Vaccine
drug_delivery_route
Intranodal, Intratumoral
drug_mechanism_of_action
Autologous type-1-polarized dendritic cells pulsed with peptides from native and mutant ESR1 are injected intranodally or intratumorally to present ESR1 epitopes via MHC class I and II, produce IL-12 to induce Th1 skewing, and prime ESR1-specific CD4+ and CD8+ T-cell responses that mediate cytotoxicity against ER/ESR1-mutant tumor cells.
drug_name
DC1 dendritic-cell vaccine (ESR1 peptide–pulsed)
nct_id_drug_ref
NCT06691035