drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy
drug_description
Partial HLA-matched multivirus-specific cytotoxic T lymphocytes administered by IV infusion to restore antiviral cellular immunity after allo-HSCT by HLA-restricted TCR recognition of CMV/EBV antigens and perforin/granzyme-mediated cytolysis.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
T-Lymphocytes, Cytotoxic
drug_category
TCR SELECTED T CELLS
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Adoptive transfer of partial HLA-matched virus-specific cytotoxic T lymphocytes that use their endogenous, HLA-restricted TCRs to recognize CMV/EBV peptides on infected cells, expand in vivo, and mediate killing via perforin/granzyme and cytokine release, thereby clearing infected cells and restoring antiviral cellular immunity after allo-HSCT.
drug_name
Virus-specific T cells (VSTs) targeting CMV and EBV
nct_id_drug_ref
NCT06075927