drug_type
RELEVANT_DRUG
intervention_type
Cellular immunotherapy (biological vaccine)
drug_description
Autologous monocyte-derived dendritic cell vaccine loaded ex vivo with Epstein–Barr virus antigens to present peptides on MHC I/II and prime/expand EBV-specific CD8+ and CD4+ T cells, promoting a Th1 response and cytotoxic killing of EBV-positive malignant cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Dendritic Cell Vaccine
drug_category
DC VACCINE
drug_class
Vaccine
drug_delivery_route
Not specified
drug_mechanism_of_action
Autologous monocyte-derived dendritic cells are loaded ex vivo with EBV antigens and, upon administration, present EBV peptides on MHC I/II to prime and expand EBV-specific CD8+ cytotoxic and CD4+ helper T cells, promoting a Th1 response and cytolytic killing of EBV-positive malignant cells.
drug_name
KSD-101 (autologous monocyte-derived dendritic cell vaccine pulsed with EBV antigens)
nct_id_drug_ref
NCT05635591