drug_type
RELEVANT_DRUG
intervention_type
monoclonal antibody
drug_description
Type II glycoengineered anti-CD20 monoclonal antibody administered IV; depletes B cells via enhanced ADCC, direct cell death, and some complement activation.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Obinutuzumab
drug_category
CYTOTOXIC ANTIBODY
drug_class
Cytotoxic protein
drug_delivery_route
Intravenous
drug_mechanism_of_action
Type II glycoengineered anti-CD20 monoclonal antibody that depletes CD20+ B cells via enhanced ADCC/ADCP, direct non-apoptotic cell death, and limited complement-dependent cytotoxicity.
drug_name
Obinutuzumab (GA101; Gazyva)
nct_id_drug_ref
NCT06108232