drug_type
RELEVANT_DRUG
intervention_type
antibody-drug conjugate (ADC)
drug_description
Anti-CLDN18.2 antibody–drug conjugate that binds CLDN18.2 on tumor cells, is internalized, and releases an MMAE payload to disrupt microtubules causing mitotic arrest and apoptosis; may also mediate Fc-dependent ADCC.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Anti-CLDN18.2 antibody–drug conjugate that binds CLDN18.2 on tumor cells, is internalized, and releases an MMAE payload to disrupt microtubules, causing mitotic arrest and apoptosis; may also mediate Fc-dependent ADCC.
drug_name
AZD0901 (sonesitatug vedotin)
nct_id_drug_ref
NCT06346392