drug_type
RELEVANT_DRUG
intervention_type
broadly neutralizing monoclonal antibody
drug_description
A broadly neutralizing monoclonal antibody targeting the V3‑glycan epitope on HIV‑1 Env (synonyms: 10‑1074‑LS, zinlirvimab); neutralizes virus and mediates Fc‑dependent effector functions (e.g., ADCC/ADCP).
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Broadly neutralizing IgG1 monoclonal antibody (10-1074-LS/zinlirvimab) that binds the V3-glycan (N332) epitope on HIV-1 Env gp120, neutralizing virus by blocking Env-mediated entry; Fc domain engagement mediates effector functions (ADCC/ADCP). LS mutations extend serum half-life.
drug_name
GS-2872
nct_id_drug_ref
NCT06071767