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drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
An intravenous MAT-Fab bispecific T-cell–engaging antibody that binds CD3 on T cells and ROR1 on tumor cells to redirect cytotoxic T lymphocytes against ROR1-positive cancers.
nci_thesaurus_concept_id
C193474
nci_thesaurus_definition
A bispecific antibody directed against both the tumor-associated antigen (TAA) receptor tyrosine kinase-like orphan receptor 1 (ROR1) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-ROR1/anti-CD3 bispecific antibody EMB-07 binds to both ROR1 expressed on tumor cells and CD3 expressed on cytotoxic T-lymphocytes (CTLs). This activates and redirects CTLs to ROR1-expressing tumor cells, which results in the CTL-mediated death of ROR1-expressing tumor cells. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis and in many types of hematological malignancies. It plays key roles in tumor cell proliferation and survival.
drug_mesh_term
Antibodies, Bispecific
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Intravenous
drug_mechanism_of_action
EMB-07 is a bispecific antibody that simultaneously binds CD3 on T cells and ROR1 on tumor cells, bringing cytotoxic T lymphocytes into close proximity with ROR1-positive cancer cells to trigger TCR/CD3 activation and perforin/granzyme-mediated tumor cell killing.
drug_name
EMB-07
nct_id_drug_ref
NCT05607498