drug_type
RELEVANT_DRUG
intervention_type
antibiotic (monobactam)
drug_description
Monobactam antibiotic that inhibits gram-negative bacterial cell-wall synthesis by binding penicillin-binding proteins.
nci_thesaurus_concept_id
C28845
nci_thesaurus_preferred_term
Aztreonam
nci_thesaurus_definition
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and death. This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms.
drug_mesh_term
Aztreonam
drug_category
SMALL MOLECULE DRUG
drug_class
Inhibitor
drug_delivery_route
Inhalation
drug_mechanism_of_action
Monobactam beta-lactam antibiotic that binds and inhibits penicillin-binding protein 3 (PBP-3) in gram-negative bacteria, blocking cell-wall peptidoglycan synthesis and leading to loss of wall integrity, lysis, and bacterial death; resistant to many beta-lactamases.
drug_name
Aztreonam
nct_id_drug_ref
NCT05777603