drug_type
RELEVANT_DRUG
intervention_type
monoclonal antibody (bNAb)
drug_description
Human IgG1 broadly neutralizing monoclonal antibody targeting the HIV-1 Env CD4-binding site; LS modification extends half-life; mediates neutralization and Fc effector functions.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Unknown
drug_mechanism_of_action
Broadly neutralizing human IgG1 antibody that binds the HIV-1 Env CD4-binding site to block viral attachment and entry, neutralizing circulating virions; Fc region mediates effector functions (e.g., ADCC/ADCP, complement) and contains LS (M428L/N434S) mutation to enhance FcRn binding and extend serum half-life.
drug_name
VRC07-523LS
nct_id_drug_ref
NCT05769569