drug_type
RELEVANT_DRUG
intervention_type
Biologic (bispecific T-cell–engaging antibody)
drug_description
Subcutaneous bispecific T‑cell–engaging antibody that binds GPRC5D on myeloma cells and CD3 on T cells, activating T‑cell cytotoxicity against GPRC5D-positive plasma cells.
nci_thesaurus_concept_id
C189961
nci_thesaurus_definition
A T-cell engaging bispecific antibody directed against both the tumor-associated antigen (TAA) G-protein coupled receptor family C group 5 member D (GPRC5D) and the T-cell surface antigen CD3, with potential antineoplastic activity. Upon administration, forimtamig binds to both GPRC5D expressed on tumor cells and CD3 on T-cells. This results in the cross-linking of T-cells and tumor cells and induces a potent cytotoxic T-lymphocyte (CTL) response against GPRC5D-expressing tumor cells. GPRC5D is overexpressed on certain tumors, such as multiple myeloma, while minimally expressed on normal, healthy cells, and plays a key role in tumor cell proliferation.
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Subcutaneous
drug_mechanism_of_action
Bispecific antibody that binds GPRC5D on myeloma cells and CD3 on T cells, cross-linking them to activate T-cell cytotoxicity and kill GPRC5D-positive plasma cells.
drug_name
Forimtamig
nct_id_drug_ref
NCT06055075