drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
Antibody–drug conjugate targeting integrin αvβ6; internalization releases the vedotin payload MMAE (monomethyl auristatin E), a microtubule-disrupting agent that causes G2/M arrest and apoptosis.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Monoclonal antibody targets integrin αvβ6 on tumor cells, is internalized, and releases the vedotin payload MMAE via a cleavable linker. MMAE disrupts microtubules by inhibiting tubulin polymerization, causing G2/M arrest and apoptosis, with potential bystander killing.
drug_name
Sigvotatug vedotin (SGN-B6A; PF-08046047)
nct_id_drug_ref
NCT06012435