drug_type
RELEVANT_DRUG
intervention_type
biologic (humanized monoclonal antibody)
drug_description
Humanized monoclonal antibody targeting CD2; blocks the CD2–LFA-3 costimulatory interaction and depletes/modulates CD2+ lymphocytes, inhibiting T/NK cell activation and cytokine release to reduce neuroinflammation.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Siplizumab
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Humanized anti-CD2 monoclonal antibody that blocks the CD2–LFA-3 costimulatory interaction and depletes/modulates CD2+ T and NK lymphocytes, thereby suppressing T-cell activation and proinflammatory cytokine release to reduce neuroinflammation.
drug_name
TCD601 (siplizumab)
nct_id_drug_ref
NCT06453668