Plasmid DNA vaccine encoding HPV16/18 E6/E7 tumor antigens designed to prime HPV-specific cellular and humoral immune responses.
Plasmid DNA vaccine encoding codon‑optimized HPV16/18 E6/E7 antigens. Following uptake by host cells, the plasmid drives expression of the E6/E7 fusion protein, which is processed and presented on MHC class I and II to elicit HPV‑specific cytotoxic T‑cell, helper T‑cell, and humoral responses. This immune activation targets and lyses tumor cells expressing HPV16/18 E6/E7 oncoproteins.
YES
INDIRECT
The DNA vaccine induces HPV16 E6/E7-specific CD8+ T cells; CTLs recognize E6 peptides on MHC I of tumor cells and kill them via perforin/granzyme-mediated apoptosis.
Plasmid DNA vaccine encoding HPV16/18 E6/E7 tumor antigens designed to prime HPV-specific cellular and humoral immune responses.
Plasmid DNA vaccine encoding codon‑optimized HPV16/18 E6/E7 antigens. Following uptake by host cells, the plasmid drives expression of the E6/E7 fusion protein, which is processed and presented on MHC class I and II to elicit HPV‑specific cytotoxic T‑cell, helper T‑cell, and humoral responses. This immune activation targets and lyses tumor cells expressing HPV16/18 E6/E7 oncoproteins.
YES
INDIRECT
DNA vaccine induces HPV16 E7–specific CD8+ T cells that recognize E7 peptides on MHC I and kill tumor cells via perforin/granzyme-mediated apoptosis.
Plasmid DNA vaccine encoding HPV16/18 E6/E7 tumor antigens designed to prime HPV-specific cellular and humoral immune responses.
Plasmid DNA vaccine encoding codon‑optimized HPV16/18 E6/E7 antigens. Following uptake by host cells, the plasmid drives expression of the E6/E7 fusion protein, which is processed and presented on MHC class I and II to elicit HPV‑specific cytotoxic T‑cell, helper T‑cell, and humoral responses. This immune activation targets and lyses tumor cells expressing HPV16/18 E6/E7 oncoproteins.
YES
INDIRECT
DNA vaccine primes E6/E7-specific cytotoxic T lymphocytes that recognize HPV18 E6–derived peptides on MHC I of tumor cells and kill them via perforin/granzyme-mediated apoptosis.
Plasmid DNA vaccine encoding HPV16/18 E6/E7 tumor antigens designed to prime HPV-specific cellular and humoral immune responses.
Plasmid DNA vaccine encoding codon‑optimized HPV16/18 E6/E7 antigens. Following uptake by host cells, the plasmid drives expression of the E6/E7 fusion protein, which is processed and presented on MHC class I and II to elicit HPV‑specific cytotoxic T‑cell, helper T‑cell, and humoral responses. This immune activation targets and lyses tumor cells expressing HPV16/18 E6/E7 oncoproteins.
YES
INDIRECT
The DNA vaccine induces HPV18 E7–specific cytotoxic T cells that recognize E7 peptides on MHC I and kill target cells via perforin/granzyme-mediated lysis.
Recombinant vaccinia viral vector vaccine expressing HPV16/18 E6/E7 tumor antigens used as a boost to enhance HPV-specific immune responses.
Recombinant vaccinia viral vector that delivers and expresses HPV16/18 E6/E7 tumor antigens in host antigen-presenting cells, leading to MHC I/II presentation and induction of HPV-specific CD8+ cytotoxic and CD4+ helper T-cell responses that target and kill E6/E7-expressing tumor cells; used as a boost to enhance HPV-directed immunity.
YES
INDIRECT
The vaccine induces HPV16 E6-specific CD8+ T cells via antigen presentation by APCs; these CTLs recognize E6 peptides on MHC I of tumor cells and kill them through perforin/granzyme-mediated cytolysis.