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Only direct cytotoxic targets are shown
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Gene NCT ID Antigen/Ligand Binding Type Drug Name Drug NCI Concept Drug Category Drug Class Drug Description Drug Mechanism of Action Target Cytotoxicity Mechanism Disease Disease Type Tissue OncoTree Main Type OncoTree Name Annotation Status
PTPRC NCT06075706 CD45 (PTPRC) antigen recognition Anti-thymocyte globulin CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody preparation that depletes T cells and provides immunosuppression. Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression. Anti-thymocyte globulin contains antibodies that bind T-cell surface antigens including CD45; bound cells are eliminated via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis). Steroid-refractory Acute Graft-versus-host Disease NON-CANCER Lymphoid manual_review_required
CD52 NCT06075706 CD52 antigen recognition Anti-thymocyte globulin CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody preparation that depletes T cells and provides immunosuppression. Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression. Polyclonal antibodies in anti-thymocyte globulin bind CD52 on lymphocytes and induce complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), leading to cell depletion. Steroid-refractory Acute Graft-versus-host Disease NON-CANCER Lymphoid manual_review_required
ITGAL NCT06075706 LFA-1 alpha chain (CD11a) antigen recognition Anti-thymocyte globulin CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody preparation that depletes T cells and provides immunosuppression. Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression. ATG contains antibodies that bind CD11a on T cells, leading to complement-dependent lysis and Fc-mediated ADCC/phagocytosis, depleting those cells. Steroid-refractory Acute Graft-versus-host Disease NON-CANCER Lymphoid manual_review_required
CD58 NCT06075706 LFA-3 (CD58) antigen recognition Anti-thymocyte globulin CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody preparation that depletes T cells and provides immunosuppression. Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression. Polyclonal antibodies in anti-thymocyte globulin bind T-cell surface antigens (including CD58/LFA-3) and trigger complement-dependent lysis and Fc-mediated ADCC/phagocytosis, depleting the bound cells. Steroid-refractory Acute Graft-versus-host Disease NON-CANCER Lymphoid manual_review_required
FAS NCT06075706 Fas (CD95) antigen recognition Anti-thymocyte globulin CYTOTOXIC ANTIBODY Cytotoxic protein Polyclonal antibody preparation that depletes T cells and provides immunosuppression. Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T lymphocytes via complement-dependent lysis and Fc-mediated effector functions (ADCC/phagocytosis), resulting in broad immunosuppression. Polyclonal antibodies in anti-thymocyte globulin bind CD95 (Fas) on T cells, triggering complement-dependent lysis and Fc-mediated ADCC/phagocytosis; cross-linking can also induce Fas-mediated apoptosis. Steroid-refractory Acute Graft-versus-host Disease NON-CANCER Lymphoid manual_review_required
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