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Gene

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antigen recognition (3404)

other (145)

receptor ligand recognition (192)

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ai (3167)

manual_review_required (574)

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CANCER (2959)

NON-CANCER (780)

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Gene	NCT ID	Antigen/Ligand	Binding Type	Drug Name	Drug Category	Drug Class	Drug Description	Drug Mechanism of Action	Target Cytotoxicity Mechanism	Disease	Disease Type	Tissue	Annotation Status
CD3E	NCT05482542	CD3E (CD3 epsilon)	antigen recognition	Rabbit anti-thymocyte globulin (rATG)	CYTOTOXIC ANTIBODY	Cytotoxic protein	Rabbit-derived polyclonal IgG targeting human T-cell antigens; depletes T cells (and some B/NK cells) via complement-dependent cytotoxicity, ADCC, and apoptosis.	Rabbit-derived polyclonal IgG that binds multiple human T‑cell antigens and depletes T cells (with some B/NK cell effects) via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, producing profound lymphodepletion.	Polyclonal antibodies in rATG bind CD3E on T cells and deplete them via complement-dependent cytotoxicity, Fc-mediated ADCC, and apoptosis.	Multiple Sclerosis, Relapsing-Remitting	NON-CANCER	CNS/Brain	ai
CD4	NCT05482542	CD4	antigen recognition	Rabbit anti-thymocyte globulin (rATG)	CYTOTOXIC ANTIBODY	Cytotoxic protein	Rabbit-derived polyclonal IgG targeting human T-cell antigens; depletes T cells (and some B/NK cells) via complement-dependent cytotoxicity, ADCC, and apoptosis.	Rabbit-derived polyclonal IgG that binds multiple human T‑cell antigens and depletes T cells (with some B/NK cell effects) via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, producing profound lymphodepletion.	rATG contains antibodies that bind CD4 on T cells; Fc engagement activates complement and recruits Fc receptor–bearing effectors to mediate CDC and ADCC, with additional apoptosis, depleting CD4+ cells.	Multiple Sclerosis, Relapsing-Remitting	NON-CANCER	CNS/Brain	ai
CD5	NCT05482542	CD5	antigen recognition	Rabbit anti-thymocyte globulin (rATG)	CYTOTOXIC ANTIBODY	Cytotoxic protein	Rabbit-derived polyclonal IgG targeting human T-cell antigens; depletes T cells (and some B/NK cells) via complement-dependent cytotoxicity, ADCC, and apoptosis.	Rabbit-derived polyclonal IgG that binds multiple human T‑cell antigens and depletes T cells (with some B/NK cell effects) via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, producing profound lymphodepletion.	rATG antibodies bind CD5 on target cells and induce complement-dependent cytotoxicity and Fc-mediated ADCC, with additional apoptosis induction, leading to direct depletion of CD5+ cells.	Multiple Sclerosis, Relapsing-Remitting	NON-CANCER	CNS/Brain	ai
CD7	NCT05482542	CD7	antigen recognition	Rabbit anti-thymocyte globulin (rATG)	CYTOTOXIC ANTIBODY	Cytotoxic protein	Rabbit-derived polyclonal IgG targeting human T-cell antigens; depletes T cells (and some B/NK cells) via complement-dependent cytotoxicity, ADCC, and apoptosis.	Rabbit-derived polyclonal IgG that binds multiple human T‑cell antigens and depletes T cells (with some B/NK cell effects) via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, producing profound lymphodepletion.	rATG polyclonal IgG binds multiple T‑cell surface antigens on CD7+ cells, triggering complement-mediated lysis (CDC), Fc receptor–mediated ADCC by effector cells, and apoptosis, leading to depletion of those cells.	Multiple Sclerosis, Relapsing-Remitting	NON-CANCER	CNS/Brain	ai
CD8A	NCT05482542	CD8A	antigen recognition	Rabbit anti-thymocyte globulin (rATG)	CYTOTOXIC ANTIBODY	Cytotoxic protein	Rabbit-derived polyclonal IgG targeting human T-cell antigens; depletes T cells (and some B/NK cells) via complement-dependent cytotoxicity, ADCC, and apoptosis.	Rabbit-derived polyclonal IgG that binds multiple human T‑cell antigens and depletes T cells (with some B/NK cell effects) via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis, producing profound lymphodepletion.	rATG binds CD8 (CD8A) on T cells and depletes them via complement-dependent cytotoxicity and Fc-mediated ADCC, with additional apoptosis induction.	Multiple Sclerosis, Relapsing-Remitting	NON-CANCER	CNS/Brain	ai