gene_symbol
IL12RB1
hgnc_id
HGNC:5971
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
This CAR T therapy targets CD19 and kills CD19+ cells via T‑cell cytotoxicity; secreted IL‑12 signals through IL‑12Rβ1 to activate immune cells but does not target IL‑12Rβ1‑expressing cells for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IL-12 receptor chain; functions as heterodimer with IL12RB2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06343376
disease_id_num_tar_ref
1099
drug_id_num_tar_ref
2996