gene_symbol
IL12RB2
hgnc_id
HGNC:5972
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
This CAR T product kills CD19+ cells via CAR-mediated cytotoxicity (perforin/granzyme). IL-12 secretion acts on IL-12Rβ2-expressing immune cells to enhance immunity, not to target them for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IL-12 receptor chain; functions as heterodimer with IL12RB1
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06343376
disease_id_num_tar_ref
1099
drug_id_num_tar_ref
2996