gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
EGFRt is a safety tag; the CAR T cells do not target EGFR. EGFRt+ cells would only be depleted if cetuximab is given, triggering NK-cell ADCC against the tagged CAR T cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Truncated non-kinase EGFR tag (EGFRt) enabling cetuximab-mediated depletion
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06343376
disease_id_num_tar_ref
1099
drug_id_num_tar_ref
2996