gene_symbol
MICA
hgnc_id
HGNC:7090
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Allogeneic double-negative T cells express NKG2D; engagement with MICA on target cells triggers MHC-independent cytotoxic degranulation (perforin/granzyme) and IFN-gamma release, leading to tumor cell lysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
NKG2D ligand
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05858814
disease_id_num_tar_ref
1100
drug_id_num_tar_ref
2999