gene_symbol
PVR
hgnc_id
HGNC:9705
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Allogeneic double‑negative T cells express DNAM‑1 (CD226) that binds CD155 (PVR) on target cells, triggering MHC‑independent cytotoxic degranulation (perforin/granzyme) and IFN‑γ release to kill the cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
DNAM-1 (CD226) ligand
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05858814
disease_id_num_tar_ref
1100
drug_id_num_tar_ref
2999