gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Rituximab binds CD20 on B cells and induces complement-dependent cytotoxicity (MAC-mediated lysis) and FcγR-mediated ADCC by NK cells/macrophages; it can also trigger apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen; binds extracellular loop epitope (type I anti-CD20)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05914155
disease_id_num_tar_ref
1102
drug_id_num_tar_ref
3005